It is a member of the 2-arylpropionic acid group of non-steroidal anti-inflammatory drugs (nsaids), and possesses anti-inflammatory, analgesic and antipyretic activity. It is a chiral drug. like most other Nsaids is an inhibitor of the enzyme cyclooxygenase of the arachidonic acid cascade. However, the inhibition of prostaglandin synthesis is slight in relation to its anti-inflammatory and analgesic potency. The precise mode of action of it is not clear. For faster pain relief in Osteoarthritis and other musculo-skeletal disorders, pre and post- orthopaedic surgery and Trauma. It is rapidly and nearly completely absorbed (more than 90% bioavailable) when administered orally. Peak blood plasma concentrations are achieved in 1-3 hours after oral administration of 1, 5, and 25 mg/kg to dogs. The mean terminal half-life of It is approximately 8 hours (range 4.5-9.8 hours). It has a small volume of distribution and a low systemic clearance. It is highly bound to plasma protein.
It is metabolized in the liver by conjunction and oxidation. The excretion of the glycuronide conjugate is mainly fecal after biliary excretion.
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