Epi-Care doesn’t work its way through the liver, making it a better choice for young dogs that need medicine for life. Absorption, distribution, and speed of metabolism can vary among dogs; published dose recommendation only serves as a general guide. Most new patients are started at the lower end of the dose range; however, patients with frequent or severe seizures are often best managed by starting at the higher side of the dose range or by using a loading dose. Unless you give a loading dose, it can take up to three or four months before it really begins work.